(conjugated estrogens)

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Contraindications

4 CONTRAINDICATIONS

PREMARIN vaginal cream is contraindicated in women with any of the following conditions:

Undiagnosed abnormal genital bleeding [see Warnings and Precautions (5.3)]
Breast cancer or a history of breast cancer [see Warnings and Precautions (5.3)]
Estrogen-dependent neoplasia [see Warnings and Precautions (5.3)]
Active DVT, PE, or a history of these conditions [see Warnings and Precautions (5.2)]
Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions [see Warnings and Precautions (5.2)]
Known anaphylactic reaction or angioedema to PREMARIN [see Warnings and Precautions (5.16,5.17)]
Hepatic impairment or disease [see Warnings and Precautions (5.11)]
Protein C, protein S or antithrombin deficiency or other known thrombophilic disorders
Medication Guide
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