What is PRISTIQ?

•

PRISTIQ is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder (MDD). PRISTIQ belongs to a class of medicines known as serotonin and norepinephrine reuptake inhibitors (SNRIs).

Do not take PRISTIQ if you:

•

are allergic to desvenlafaxine succinate, venlafaxine hydrochloride, or any of the ingredients in PRISTIQ. See the end of this Medication Guide for a complete list of ingredients in PRISTIQ.

•

take a monoamine oxidase inhibitor (MAOI).

•

have stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI.

•

are being treated with the antibiotic linezolid or the intravenous methylene blue.

Do not start taking an MAOI for at least 7 days after you stop treatment with PRISTIQ.

Before taking PRISTIQ tell your healthcare provider about all your medical conditions, including if you:

•

have high blood pressure

•

have heart problems

•

have cerebrovascular problems or had a stroke

•

have or had bleeding problems

•

have, or have a family history of, bipolar disorder, mania or hypomania

•

have high cholesterol or high triglycerides

•

have or had depression, suicidal thoughts or behavior

•

have kidney or liver problems

•

have or had seizures or convulsions

•

have low sodium levels in your blood

•

are pregnant or plan to become pregnant. Talk to your healthcare provider about the risk to your unborn baby if you take PRISTIQ during pregnancy.

o

Tell your healthcare provider if you become pregnant or think you are pregnant during treatment with PRISTIQ.

o

If you become pregnant during treatment with PRISTIQ, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants. You can register by calling 1-844-405-6185.

•

are breastfeeding or plan to breastfeed. PRISTIQ can pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with PRISTIQ.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
PRISTIQ and other medicines may affect each other causing possible serious side effects. PRISTIQ may affect the way other medicines work and other medicines may affect the way PRISTIQ works.
Especially tell your healthcare provider if you take:

•

other MAOIs

•

medicines to treat migraine headaches known as triptans

•

tricyclic antidepressants

•

lithium

•

tramadol, fentanyl, meperidine, methadone, or other opioids

•

tryptophan

•

buspirone

•

amphetamines

•

St. John's Wort

•

other medicines containing desvenlafaxine or venlafaxine

•

medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin

•

medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)

Ask your healthcare provider if you are not sure if you are taking any of these medicines. Your healthcare provider can tell you if it is safe to take PRISTIQ with your other medicines.
Do not start or stop any other medicines during treatment with PRISTIQ without talking to your healthcare provider first. Stopping PRISTIQ suddenly may cause you to have serious side effects. See, "What are the possible side effects of PRISTIQ?"
Know the medicines you take. Keep a list of them to show to your healthcare providers when you get a new medicine.