(conjugated estrogens and medroxyprogesterone acetate)

Medication Guide

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Health Professional Information

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Prescribing Information

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Health Professional Information

Who should not take PREMPRO or PREMPHASE?

Who should not take PREMPRO or PREMPHASE?

Do not take PREMPRO or PREMPHASE if you have had your uterus (womb) removed (hysterectomy).

PREMPRO and PREMPHASE contain a progestin to decrease the chance of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and you should not take PREMPRO or PREMPHASE.

Do not take PREMPRO or PREMPHASE if you:

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Have unusual vaginal bleeding
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Currently have or have had certain cancers
Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use PREMPRO or PREMPHASE.
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Had a stroke or heart attack
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Currently have or have had blood clots
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Currently have or have had liver problems
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Have been diagnosed with a bleeding disorder
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Are allergic to PREMPRO or PREMPHASE or any of their ingredients
See the list of ingredients in PREMPRO and PREMPHASE at the end of this leaflet.

Tell your healthcare provider

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If you have any unusual vaginal bleeding
Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
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About all of your medical problems
Your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
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About all the medicines you take
This includes prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how PREMPRO or PREMPHASE works. PREMPRO or PREMPHASE may also affect how your other medicines work.
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If you are going to have surgery or will be on bedrest
You may need to stop taking PREMPRO or PREMPHASE.
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If you are pregnant or think you may be pregnant

PREMPRO and PREMPHASE are not for pregnant women.

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If you are breastfeeding
The hormones in PREMPRO and PREMPHASE can pass into your breast milk.

Additional Resources

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