(conjugated estrogens and medroxyprogesterone acetate)

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What are the possible side effects of PREMPRO or PREMPHASE?

What are the possible side effects of PREMPRO or PREMPHASE?

Side effects are grouped by how serious they are and how often they happen when you are treated.

Serious, but less common side effects include:

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Heart attack
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Stroke
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Blood clots
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Breast cancer
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Cancer of the lining of the uterus (womb)
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Cancer of the ovary
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Dementia
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High or low blood calcium
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Gallbladder disease
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Visual abnormalities
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High blood pressure
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High levels of fat (triglycerides) in your blood
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Liver problems
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Changes in your thyroid hormone levels
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Fluid retention
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Cancer changes of endometriosis
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Enlargement of benign tumors of the uterus ("fibroids")
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Severe allergic reactions
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Changes in certain laboratory test results, such as high blood sugar

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

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New breast lumps
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Unusual vaginal bleeding
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Changes in vision or speech
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Sudden new severe headaches
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Severe pains in your chest or legs with or without shortness of breath, weakness and fatigue
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Swelling of the face, lips, and tongue with or without red itchy bumps

Common side effects of PREMPRO or PREMPHASE include:

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Headache
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Breast pain
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Irregular vaginal bleeding or spotting
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Stomach or abdominal cramps, bloating
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Nausea and vomiting
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Hair loss
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Fluid retention
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Vaginal yeast infection

These are not all the possible side effects of PREMPRO or PREMPHASE. For more information, ask your healthcare provider or pharmacist for advice about side effects. You may report side effects to Pfizer Inc. at 1-800-438-1985 or to FDA at 1-800-FDA-1088.

Additional Resources

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Submit a medical question for a Pfizer medicine or a vaccine. 

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To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this medication, click the link below to submit your information: 
Pfizer Safety Reporting Site

*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.

If you cannot use the above website to report an adverse event related to a Pfizer medication, please call (800) 438-1985.

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or by calling (800) 332-1088.