(conjugated estrogens)

Medication Guide

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Prescribing Information

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Who should not use PREMARIN vaginal cream?

Who should not use PREMARIN vaginal cream?

Do not start using PREMARIN vaginal cream if you:

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Have unusual vaginal bleeding
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Currently have or have had certain cancers
Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use PREMARIN vaginal cream.
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Had a stroke or heart attack
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Currently have or have had blood clots
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Currently have or have had liver problems
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Have been diagnosed with a bleeding disorder
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Are allergic to PREMARIN vaginal cream or any of its ingredients
See the end of this leaflet for a list of ingredients in PREMARIN vaginal cream.

Tell your healthcare provider:

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If you have unusual vaginal bleeding
Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
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About all of your medical problems
Your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
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About all the medicines you take
This includes prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how PREMARIN vaginal cream works. PREMARIN vaginal cream may also affect how your other medicines work.
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If you are going to have surgery or will be on bedrest

You may need to stop using PREMARIN vaginal cream.

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If you are pregnant or think you may be pregnant

PREMARIN vaginal cream is not for pregnant women

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If you are breast feeding

The hormones in PREMARIN vaginal cream can pass into your breast milk.

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