What is the most important information I should know about PREMARIN vaginal cream (an estrogen mixture)?

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Using estrogen-alone may increase your chance of getting cancer of the uterus (womb)
Report any unusual vaginal bleeding right away while you are using PREMARIN vaginal cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

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Do not use estrogen-alone to prevent heart disease, heart attacks, strokes or dementia (decline in brain function)

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Using estrogen-alone may increase your chances of getting strokes or blood clots

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Using estrogen-alone may increase your chance of getting dementia, based on a study of women of 65 years of age or older

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Do not use estrogens with progestins to prevent heart disease, heart attacks, strokes, or dementia

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Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots

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Using estrogens with progestins may increase your chance of getting dementia, based on a study of women age 65 years of age or older

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You and your healthcare provider should talk regularly about whether you still need treatment with PREMARIN vaginal cream