(nirmatrelvir tablets; ritonavir tablets)

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What is the most important information I should know about PAXLOVID?

What is the most important information I should know about PAXLOVID?

PAXLOVID can interact with other medicines causing severe or life-threatening side effects or death. It is important to know the medicines that should not be taken with PAXLOVID.

Do not take PAXLOVID if:

•
you are taking any of the following medicines:
o
alfuzosin
o
amiodarone
o
apalutamide
o
carbamazepine
o
colchicine
o
dihydroergotamine
o
dronedarone
o
eletriptan
o
enzalutamide
o
eplerenone
o
ergotamine
o
finerenone
o
flecainide
o
flibanserin
o
ivabradine
o
lomitapide
o
lovastatin
o
lumacaftor/ivacaftor
o
lurasidone
o
methylergonovine
o
midazolam (oral)
o
naloxegol
o
phenobarbital
o
phenytoin
o
pimozide
o
primidone
o
propafenone
o
quinidine
o
ranolazine
o
rifampin
o
rifapentine
o
St. John’s Wort (hypericum perforatum)
o
sildenafil (Revatio®) for pulmonary arterial hypertension
o
silodosin
o
simvastatin
o
tolvaptan
o
triazolam
o
ubrogepant
o
voclosporin

These are not the only medicines that may cause serious or life-threatening side effects if taken with PAXLOVID. PAXLOVID may increase or decrease the levels of multiple other medicines. It is very important to tell your healthcare provider about all of the medicines you are taking because additional laboratory tests or changes in the dose of your other medicines may be necessary during treatment with PAXLOVID. Your healthcare provider may also tell you about specific symptoms to watch out for that may indicate that you need to stop or decrease the dose of some of your other medicines.

•
you are allergic to nirmatrelvir, ritonavir, or any of the ingredients in PAXLOVID. See the end of this leaflet for a complete list of ingredients in PAXLOVID. See “What are the possible side effects of PAXLOVID?” for signs and symptoms of allergic reactions.

Additional Resources

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Pfizer Safety Reporting Site

*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.

If you cannot use the above website to report an adverse event related to a Pfizer medication, please call (800) 438-1985.

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or by calling (800) 332-1088.