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What is the most important information I should know about medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

What is the most important information I should know about medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

NSAIDs can cause serious side effects, including:

•
Increased risk of a heart attack or stroke that can lead to death. This risk may happen early in treatment and may increase:
•
with increasing doses of NSAIDs
•
with longer use of NSAIDs

Do not take NSAIDs right before or after a heart surgery called a "coronary artery bypass graft (CABG)."

Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.

•
Increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach and intestines:
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anytime during use
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without warning symptoms
•
that may cause death

The risk of getting an ulcer or bleeding increases with:

•   past history of stomach ulcers,                                                   •   increasing doses of NSAIDs
    or stomach or intestinal                                                               •   longer use of NSAIDs
    bleeding with the use of                                                              •   smoking
    NSAIDs                                                                                       •   drinking alcohol
•   taking medicines called                                                              •   older age
    "corticosteroids",                                                                        •   poor health
    "anticoagulants", "SSRIs", or                                                     •   advanced liver disease
    "SNRIs"                                                                                      •   bleeding problems

NSAIDs should only be used:

•
exactly as prescribed
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at the lowest dose possible for your treatment
•
for the shortest time needed

Additional Resources

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To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this medication, click the link below to submit your information: 
Pfizer Safety Reporting Site

*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.

If you cannot use the above website to report an adverse event related to a Pfizer medication, please call (800) 438-1985.

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or by calling (800) 332-1088.