(estradiol)

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What are the possible side effects of estrogens?

What are the possible side effects of estrogens?

Side effects are grouped by how serious they are and how often they happen when you are treated.

Serious, but less common side effects include:

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heart attack
•
stroke
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blood clots
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dementia
•
breast cancer
•
cancer of the lining of the uterus (womb)
•
cancer of the ovary
•
high blood pressure
•
high blood sugar
•
gallbladder disease
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liver problems
•
changes in your thyroid hormone levels
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enlargement of benign tumors of the uterus ("fibroids")

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

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new breast lumps
•
unusual vaginal bleeding
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changes in vision or speech
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sudden new severe headaches
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severe pains in your chest or legs with or without shortness of breath, weakness and fatigue
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memory loss or confusion

Less serious, but common side effects include:

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headache
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breast pain
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irregular vaginal bleeding or spotting
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stomach or abdominal cramps, bloating
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nausea and vomiting
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fluid retention
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vaginal yeast infection

These are not all the possible side effects of ESTRING. For more information, ask your healthcare provider or pharmacist for advice about side effects. Tell your healthcare provider if you have any side effect that bothers you or does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to Pfizer at 1-800-438-1985.

Additional Resources

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Speak with a Pfizer Medical Information Professional regarding your Pfizer medicine or vaccine inquiry.

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Submit a medical question for a Pfizer medicine or a vaccine. 

The submission will be reviewed during our standard business hours.

To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this medication, click the link below to submit your information: 
Pfizer Safety Reporting Site

*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.

If you cannot use the above website to report an adverse event related to a Pfizer medication, please call (800) 438-1985.

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or by calling (800) 332-1088.