WHAT ARE THE MOST SERIOUS RISKS OF depo-subQ provera 104?

Losing calcium from your bones. Depo-subQ provera 104 use may decrease the amount of calcium in your bones. The longer you use depo-subQ provera 104, the more calcium you are likely to lose. This increases the risk of your bones weakening if you use depo-subQ provera 104 continuously for a long time (for example, if you use depo-subQ provera 104 for more than 2 years). The loss of calcium may increase your risk of osteoporosis and broken bones, particularly after your menopause.

Calcium is generally added to the bones during teenage years. The decrease of calcium in your bones is of most concern if you are a teenager or have the following risk factors:

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Bone disease

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Anorexia nervosa (an eating disorder)

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A strong family history of osteoporosis

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Using a drug that can lower the amount of calcium in bones (drugs for epilepsy or steroids), or

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Drinking a lot of alcohol or smoking a lot

If you need a birth control method for more than 2 years, your healthcare professional may ask you to have a test of your bones or ask you to switch to another birth control method before continuing depo-subQ provera 104, especially if you have other risks for weak bones. When depo-subQ provera 104 is stopped, the calcium in your bones begins to come back. The lost calcium may not return completely once you stop using depo-subQ provera 104.

Abnormal or very heavy bleeding. If you start having very heavy or very long periods, tell your healthcare professional.

Allergic reaction. Allergic reactions to depo-subQ provera 104 have been reported. If you have hives, problems breathing, swelling of the face, mouth, tongue, or neck, or just do not feel right after your shot, call your healthcare professional or go to the Emergency Room right away.

Serious blood clots. Call your healthcare professional immediately if you:

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Have sharp chest pain, cough blood, or suddenly have trouble breathing

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Have a sudden severe headache with vomiting, blindness or trouble talking, weakness, or numbness in an arm or leg, or get dizzy or faint

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Have swelling or severe pain in your leg

Depression. If you suffer from depression or have a history of depression, inform your healthcare professional if you notice any worsening of your depression while taking depo-subQ provera 104.