QT interval prolongation and ventricular arrhythmias can occur with Oxaliplatin [see Warnings and Precautions (5.7)]. Avoid coadministration of Oxaliplatin with medicinal products with a known potential to prolong the QT interval.
Because platinum-containing species are eliminated primarily through the kidney, clearance of these products may be decreased by coadministration of potentially nephrotoxic compounds [see Clinical Pharmacology (12.3)]. Avoid coadministration of Oxaliplatin with medicinal products known to cause nephrotoxicity.
Prolonged prothrombin time and INR occasionally associated with hemorrhage have been reported in patients who received Oxaliplatin with fluorouracil/leucovorin while on anticoagulants [see Warnings and Precautions (5.9), Adverse Reactions (6.2)]. Increase frequency of monitoring in patients who are receiving Oxaliplatin with fluorouracil/leucovorin and oral anticoagulants.
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