Prescribing Information
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4 CONTRAINDICATIONS

4 CONTRAINDICATIONS

Preservative-free morphine sulfate injection is contraindicated in patients with:

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Significant respiratory depression [see Warnings and Precautions (5.3)]
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Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [see Warnings and Precautions (5.9)]
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Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days [see Warnings and Precautions (5.10), Drug Interactions (7)]
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Known or suspected gastrointestinal obstruction, including paralytic ileus [see Warnings and Precautions (5.14)]
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Hypersensitivity to morphine (e.g., anaphylaxis) [see Adverse Reactions (6)]

Neuraxial administration of preservative-free morphine sulfate injection is contraindicated in patients with:

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Infection at the injection microinfusion site [see Warnings and Precautions (5.1)]
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Concomitant anticoagulant therapy [see Warnings and Precautions (5.1)]
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Uncontrolled bleeding diathesis [see Warnings and Precautions (5.1)]
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The presence of any other concomitant therapy or medical condition which would render epidural or intrathecal administration of medication especially hazardous.

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