(ritlecitinib)
Table 3 includes clinically significant drug interactions affecting other drugs.
CYP3A Substrates Where Small Concentration Changes May Lead to Serious Adverse Reactions | |
Clinical Impact | Ritlecitinib is a CYP3A inhibitor. Concomitant use of ritlecitinib increases AUC and Cmax of CYP3A substrates [see Clinical Pharmacology (12.3)], which may increase the risk of adverse reactions of these substrates. |
Intervention | Consider additional monitoring and dosage adjustment in accordance with approved product labeling of CYP3A substrates where small concentration changes may lead to serious adverse reactions when used with LITFULO. |
CYP1A2 Substrates Where Small Concentration Changes May Lead to Serious Adverse Reactions | |
Clinical Impact | Ritlecitinib is a CYP1A2 inhibitor. Concomitant use of ritlecitinib increases AUC and Cmax of CYP1A2 substrates [see Clinical Pharmacology (12.3)], which may increase the risk of adverse reactions of these substrates. |
Intervention | Consider additional monitoring and dosage adjustment in accordance with the approved product labeling of CYP1A2 substrates where small concentration changes may lead to serious adverse reactions when used concomitantly with LITFULO. |
Table 4 includes clinically significant drug interactions affecting LITFULO.
CYP3A Inducers | |
Clinical Impact | Concomitant use of strong CYP3A inducer (e.g., rifampin) may decrease AUC and Cmax of ritlecitinib [see Clinical Pharmacology (12.3)], which may result in loss of or reduced clinical response. |
Intervention | Coadministration with strong inducers of CYP3A is not recommended. |
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