Carcinogenesis
Studies of lidocaine hydrochloride in animals to evaluate the carcinogenic potential have not been conducted.
Mutagenesis
Studies of lidocaine hydrochloride in animals to evaluate the mutagenic potential have not been conducted.
Impairment of Fertility
In a published study, female Sprague-Dawley rats were treated subcutaneously with lidocaine via osmotic pumps starting two weeks prior to mating, and reproductive effects were assessed. Rats dosed up to the high dose of 500 mg/kg/day (approximately 45 times the MRDD on a mg/m2 basis) showed no effects on copulatory rate, pregnancy rate, numbers of corpora lutea, or implantations.
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