(Epinephrine injection, USP ABBOJECT™)

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Drug Interactions

7 DRUG INTERACTIONS

7.1 Drugs Antagonizing Pressor Effects of Epinephrine

α-blockers, such as phentolamine
Vasodilators, such as nitrates
Diuretics
Antihypertensives
Ergot alkaloids
Phenothiazine antipsychotics

7.2 Drugs Potentiating Pressor Effects of Epinephrine

Sympathomimetics
β-blockers, such as propranolol
Tricyclic anti-depressants
Monoamine oxidase (MAO) inhibitors
Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone
Clonidine
Doxapram
Oxytocin

7.3 Drugs Potentiating Arrhythmogenic Effects of Epinephrine

Patients who are concomitantly receiving any of the following drugs should be observed carefully for the development of cardiac arrhythmias [see Warnings and Precautions (5.5) and Adverse Reactions (6)].

β-blockers, such as propranolol
Cyclopropane or halogenated hydrocarbon anesthetics, such as halothane
Antihistamines
Thyroid hormones
Diuretics
Cardiac glycosides, such as digitalis glycosides
Quinidine

7.4 Drugs Potentiating Hypokalemic Effects of Epinephrine

Potassium depleting diuretics
Corticosteroids
Theophylline
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