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PREPARATION OF INTRAVENOUS SOLUTIONS
Carboplatin Injection 10 mg/mL is supplied as a Ready To Use (RTU) sterile solution in 5 mL, 15 mL, 45 mL or 60 mL vials. Total content of carboplatin per vial is described in following table:
| Vial Strength | Diluent Volume |
|---|---|
50 mg | 5 mL |
150 mg | 15 mL |
450 mg | 45 mL |
600 mg | 60 mL |
Carboplatin Injection aqueous solution can be further diluted to concentrations as low as 0.5 mg/mL with 5% Dextrose in Water (D5W) or 0.9% Sodium Chloride Injection, USP.
When prepared as directed, Carboplatin Injection aqueous solutions are stable for 8 hours at room temperature (25°C). Since no antibacterial preservative is contained in the formulation, it is recommended that Carboplatin Injection aqueous solutions be discarded 8 hours after dilution.
HANDLING AND DISPOSAL
Caution should be exercised in handling and preparing Carboplatin Injection. Several guidelines on this subject have been published.1–4
To minimize the risk of dermal exposure, always wear impervious gloves when handling vials containing Carboplatin Injection. If Carboplatin Injection contacts the skin, immediately wash the skin thoroughly with soap and water. If Carboplatin Injection contacts mucous membranes, the membranes should be flushed immediately and thoroughly with water. More information is available in the references listed below.
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